Exhibit 99.1

TACTILE SYSTEMS TECHNOLOGY, INC. REPORTS THIRD QUARTER 2022 FINANCIAL RESULTS; RAISES FULL YEAR 2022 OUTLOOK

Third Quarter Revenue Increased 24% Year-Over-Year; First Nine Months Revenue Increased 18% Year-Over-Year

MINNEAPOLIS, MN, November 7, 2022 – Tactile Systems Technology, Inc. (“Tactile Medical”) (Nasdaq: TCMD), a medical technology company focused on developing medical devices for the treatment of patients with underserved chronic diseases at home, today reported financial results for the third quarter and nine months ended September 30, 2022.

Third Quarter 2022 Summary:

Third Quarter 2022 Highlights:

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“We are excited to deliver total revenue performance that exceeded our expectations for the third quarter,” said Dan Reuvers, President and Chief Executive Officer of Tactile Medical. “Sales of our airway clearance products benefited from strong demand by our DME channel partners, as their sales reps continued to adopt our technology and identify patients in need of treatment among their existing customers. In our lymphedema business, we were pleased to see improvement in patient volumes at the clinics we serve, along with a positive initial response following the full market release of our ComfortEase garments. Importantly, in addition to our strong sales performance, we also delivered significant improvements in our profitability, increasing our gross, operating and adjusted EBITDA margins compared to the prior year quarter.”

Mr. Reuvers continued, “We are raising our guidance today to reflect our stronger-than-anticipated third quarter results. We remain focused on continued execution with respect to our four objectives for the second half of 2022: improving the productivity of our recently expanded salesforce, facilitating the introduction of our new products, supporting our DME channel partners and improving profitability. By continuing to execute on these objectives, we aim to position Tactile Medical for sustainable growth and improving profitability.”

Third Quarter 2022 Financial Results

Total revenue in the third quarter of 2022 increased $12.8 million, or 24%, to $65.3 million, compared to $52.5 million in the third quarter of 2021. The increase in total revenue was attributable to an increase of $10.2 million in sales of the airway clearance product line, which includes the AffloVest product acquired on September 8, 2021, and an increase of $2.6 million, or 5%, in sales and rentals of the lymphedema product line compared to the third quarter of 2021.

Gross profit in the third quarter of 2022 increased $9.8 million, or 27%, to $46.8 million, compared to $37.0 million in the third quarter of 2021. Gross margin was 71.7% of revenue, compared to 70.4% of revenue in the third quarter of 2021. Non-GAAP gross margin was 72.2% of revenue, compared to 71.8% of revenue in the third quarter of 2021.

Operating expenses in the third quarter of 2022 increased $10.1 million, or 26%, to $48.4 million, compared to $38.3 million in the third quarter of 2021.

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Operating loss was $1.6 million in the third quarter of 2022, compared to $1.4 million in the third quarter of 2021. Non-GAAP operating income in the third quarter of 2022 was $3.9 million, compared to $1.0 million in the third quarter of 2021.

Other expense was $0.7 million in the third quarter of 2022, compared to $0.1 million in the third quarter of 2021. The change in other expense was primarily due to an increase in interest expense.

Income tax benefit was $77,000 in the third quarter of 2022, compared to an expense of $1.9 million in the third quarter of 2021. The difference is related to a full valuation allowance being recorded against all net deferred tax assets in the current year period, whereas no valuation allowance was recorded in the third quarter of 2021.

Net loss in the third quarter of 2022 was $2.3 million, or $0.11 per diluted share, compared to $3.4 million, or $0.17 per diluted share, in the third quarter of 2021. Non-GAAP net income in the third quarter of 2022 was $1.9 million, compared to non-GAAP net loss $1.6 million in the third quarter of 2021.

Weighted average shares used to compute diluted net loss per share were 20.1 million and 19.8 million for the third quarters of 2022 and 2021, respectively.

Adjusted EBITDA was $7.2 million in the third quarter of 2022, compared to $4.1 million in the third quarter of 2021.

First Nine Months 2022 Financial Results:

Total revenue for the nine months ended September 30, 2022, increased $26.6 million, or 18%, to $172.9 million, compared to $146.3 million for the nine months ended September 30, 2021. The increase in revenue was attributable to an increase of $25.5 million in sales of the airway clearance product line, and an increase of $1.0 million, or 1%, in sales and rentals of the lymphedema product line.

Net loss for the nine months ended September 30, 2022, was $22.5 million, or $1.12 per diluted share, compared $4.3 million, or $0.22 per diluted share, for the nine months ended September 30,

2021. Non-GAAP net loss for the nine months ended September 30, 2022, was $9.5 million, compared to $1.1 million for the nine months ended September 30, 2021.

Weighted average shares used to compute diluted net loss per share were 20.0 million and 19.7 million for the nine months ended September 30, 2022 and 2021, respectively.

Adjusted EBITDA was $6.2 million in the nine months ended September 30, 2022, compared to $8.2 million in the nine months ended September 30, 2021.

Balance Sheet Summary

As of September 30, 2022, the Company had $23.4 million in cash and cash equivalents and $49.8 million of outstanding borrowings under its credit agreement, compared to $28.2 million in cash and cash equivalents and $55.0 million of outstanding borrowings under its credit agreement as of December 31, 2021. At June 30, 2022, the Company had $23.4 million in cash and cash equivalents.

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2022 Financial Outlook

The Company now expects full year 2022 total revenue in the range of $242.0 million to $245.0 million, representing growth of approximately 16% to 18% year-over-year, compared to total revenue of $208.1 million in 2021. The Company’s prior 2022 revenue guidance expectations called for total revenue in the range of $238.0 million to $242.0 million, representing growth of approximately 14% to 16% year-over-year.

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Conference Call

Management will host a conference call at 5:00 p.m. Eastern Time on November 7, 2022, to discuss the results of the quarter with a question-and-answer session. Those who would like to participate may dial 877-407-3088 (201-389-0927 for international callers) and provide access code 13733034. A live webcast of the call will also be provided on the investor relations section of the Company's website at investors.tactilemedical.com.

For those unable to participate, a replay of the call will be available for two weeks at 877-660-6853 (201-612-7415 for international callers); access code 13733034. The webcast will be archived at investors.tactilemedical.com.

About Tactile Systems Technology, Inc. (DBA Tactile Medical)

Tactile Medical is a leader in developing and marketing at-home therapies for people suffering from underserved, chronic conditions including lymphedema, lipedema, chronic venous insufficiency and chronic pulmonary disease by helping them live better and care for themselves at home. The company collaborates with clinicians to expand clinical evidence, raise awareness, increase access to care, reduce overall healthcare costs and improve the quality of life for tens of thousands of patients each year.

Legal Notice Regarding Forward-Looking Statements

This release contains forward-looking statements. Forward-looking statements are generally identifiable by the use of words like “may,” “will,” “should,” “could,” “expect,” “anticipate,” “estimate,”

“believe,” “intend,” “continue,” “confident,” “outlook,” “guidance,” “project,” “goals,” “look forward,” “poised,” “designed,” “plan,” “return,” “focused,” “prospects” or “remain” or the negative of these words or other variations on these words or comparable terminology. The reader is cautioned not to put undue reliance on these forward-looking statements, as these statements are subject to numerous factors and uncertainties outside of the Company’s control that can make such statements untrue, including, but not limited to, the impacts of the COVID-19 pandemic on the Company’s business, financial condition and results of operations, and the Company’s inability to mitigate such impacts; the adequacy of the Company’s liquidity to pursue its business objectives; the Company’s ability to obtain reimbursement from third party payers for its products; loss or retirement of key executives, including prior to identifying a successor; adverse economic conditions or intense competition; loss of a key supplier; entry of new competitors and products; adverse federal, state and local government regulation; technological obsolescence of the Company’s products; technical problems with the Company’s research and products; the Company’s ability to expand its business through strategic acquisitions; the Company’s ability to integrate acquisitions and related businesses; wage and component price inflation; the effects of current and future U.S. and foreign trade policy and tariff actions; or the inability to carry out research, development and commercialization plans. In addition, other factors that could cause actual results to differ materially are discussed in the Company’s filings with the SEC. Investors and security holders are urged to read these documents free of charge on the SEC’s website at http://www.sec.gov. The Company undertakes no obligation to publicly update or revise its forward-looking statements as a result of new information, future events or otherwise.

Use of Non-GAAP Financial Measures

This press release includes the non-GAAP financial measures of Adjusted EBITDA, non-GAAP gross margin, non-GAAP operating income (loss), and non-GAAP net income (loss), which differ from financial measures calculated in accordance with U.S. generally accepted accounting principles (“GAAP”).

Adjusted EBITDA in this release represents net income or loss, plus interest expense, net, or less interest income, net, less income tax benefit or plus income tax expense, plus depreciation and amortization, plus stock-based compensation expense, plus impairment charges and inventory write-offs, plus acquisition costs, plus litigation defense costs, plus or minus the change in fair value of earn-out, and plus executive transition costs. Non-GAAP gross margin in this release represents gross margin plus non-cash intangible amortization expense, inventory write-offs, and inventory purchase price adjustments. Non-GAAP operating income (loss) in this release represents operating income (loss) adjusted for non-cash intangible amortization expense, inventory write-offs, inventory purchase price adjustments, acquisition costs and expenses, change in fair value of earn-out, litigation defense costs and executive transition expenses. Non-GAAP net income (loss) represents net income (loss) adjusted for non-cash intangible amortization expense, inventory write-offs, inventory purchase price adjustments, acquisition costs and expenses, change in fair value of earn-out, litigation defense costs and executive transition expenses and adjusted for the income tax effect on reconciling items. Reconciliations of these non-GAAP financial measures to their most directly comparable GAAP measures are included in this press release.

These non-GAAP financial measures are presented because the Company believes they are useful indicators of its operating performance. Management uses these measures principally as measures

of the Company’s operating performance and for planning purposes, including the preparation of the Company’s annual operating plan and financial projections. The Company believes these measures are useful to investors as supplemental information and because they are frequently used by analysts, investors and other interested parties to evaluate companies in its industry. The Company also believes these non-GAAP financial measures are useful to its management and investors as a measure of comparative operating performance from period to period. In addition, Adjusted EBITDA is used as a performance metric in the Company’s compensation program.

The non-GAAP financial measures presented in this release should not be considered as an alternative to, or superior to, their respective GAAP financial measures, as measures of financial performance or cash flows from operations as a measure of liquidity, or any other performance measure derived in accordance with GAAP, and they should not be construed to imply that the Company’s future results will be unaffected by unusual or non-recurring items. In addition, Adjusted EBITDA is not intended to be a measure of free cash flow for management’s discretionary use, as it does not reflect certain cash requirements such as tax payments, debt service requirements, capital expenditures and certain other cash costs that may recur in the future. Adjusted EBITDA contains certain other limitations, including the failure to reflect our cash expenditures, cash requirements for working capital needs and cash costs to replace assets being depreciated and amortized. In evaluating non-GAAP financial measures, you should be aware that in the future the Company may incur expenses that are the same as or similar to some of the adjustments in this presentation. The Company’s presentation of non-GAAP financial measures should not be construed to imply that its future results will be unaffected by any such adjustments. Management compensates for these limitations by primarily relying on the Company’s GAAP results in addition to using non-GAAP financial measures on a supplemental basis. The Company’s definition of these non-GAAP financial measures is not necessarily comparable to other similarly titled captions of other companies due to different methods of calculation.

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The following table summarizes revenue by product line for the three and nine months ended September 30, 2022 and 2021:

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The following table contains a reconciliation of gross margin to non-GAAP gross margin:

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The following table contains a reconciliation of GAAP operating loss to non-GAAP operating income (loss):

The following table contains a reconciliation of GAAP net loss to non-GAAP net income (loss):

The following table contains a reconciliation of net loss to Adjusted EBITDA for the three and nine months ended September 30, 2022 and 2021, as well as the dollar and percentage change between the comparable periods: